endonexin

Calcium-dependent membrane-binding protein located on the endoplasmic reticulum of fibroblasts. Isolated protein will bind to liposomes if 1-10 m M calcium is present but not if the liposomes contain sphingomyelin or cholesterol. An analogous calcium-dependent membrane-binding protein, synexin, codistributes with endonexin and binds particularly to phosphatidyl-serine. Another of the same class is p36, a component of brush-border membrane, a target for the < src-gene>> tyrosine kinase, and that binds phosphatidyl serine or phosphatidyl inositol.